One-Pot Cajun Chicken Alfredo

Featured in: One-Pot Comfort Meals

This creamy one-pot meal combines tender chicken with al dente orzo pasta, simmered in a rich Cajun Alfredo sauce. Sautéed onions and garlic build a fragrant base, while smoked paprika and Cajun seasoning add a bold, zesty kick. The dish finishes with Parmesan cheese and fresh parsley for a comforting, flavorful dinner ready in just 30 minutes. Perfect for quick, satisfying meals that balance spice and creaminess.

Updated on Sun, 23 Nov 2025 10:55:00 GMT
Creamy One-Pot Cajun Chicken Alfredo Orzo features tender chicken and zesty sauce, ready in 30 minutes. Save
Creamy One-Pot Cajun Chicken Alfredo Orzo features tender chicken and zesty sauce, ready in 30 minutes. | cloverhearth.com

A quick and creamy one-pot meal that blends tender chicken, al dente orzo, and a zesty Cajun Alfredo sauce. Perfect for busy weeknights, this dish delivers bold flavors and comforting richness in just 30 minutes.

I first served this to my family on a busy weeknight and everyone went back for seconds. The creamy sauce combined with the Cajun spices makes it a memorable dish.

Ingredients

  • Chicken: 1 lb (450 g) chicken breast, diced (substitute with shrimp or Andouille sausage if desired); salt and black pepper, to taste
  • Spice Blend: 1 tbsp Cajun seasoning (adjust for spice preference); 1 tsp smoked paprika (regular paprika can be used); 1/4 tsp red pepper flakes (optional, for extra heat)
  • Base: 2 tbsp olive oil; 2 tbsp butter; 1 medium onion, chopped (yellow or sweet preferred); 3 cloves garlic, minced
  • Pasta: 1 cup (190 g) orzo pasta (substitute with other small pasta if needed)
  • Sauce: 2 cups (480 ml) low sodium chicken broth; 1 cup (240 ml) heavy cream (or half and half for a lighter version); 1 cup (90 g) Parmesan cheese, freshly grated
  • Garnish: 1 tbsp fresh parsley, chopped

Instructions

Step 1:
Heat olive oil and butter in a large skillet over medium high heat. Add diced chicken, season with salt and pepper, and sear for 3 4 minutes until golden brown. Remove chicken and set aside.
Step 2:
In the same skillet, add chopped onion and sauté for 2 3 minutes until translucent. Stir in minced garlic and cook for 1 minute until fragrant.
Step 3:
Add orzo pasta to the skillet, stirring to combine. Toast for 1 2 minutes until lightly golden.
Step 4:
Pour in chicken broth and sprinkle in Cajun seasoning, smoked paprika, and red pepper flakes. Stir well, bring to a boil, then reduce heat to low. Cover and simmer for 10 12 minutes, stirring occasionally, until orzo is al dente and most of the liquid is absorbed.
Step 5:
Remove skillet from heat. Gradually stir in heavy cream and Parmesan cheese until the sauce is creamy and smooth.
Step 6:
Return the cooked chicken to the skillet and stir to combine. Heat through for 1 minute. Taste and adjust seasoning as needed.
Step 7:
Garnish with fresh parsley before serving.
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This recipe always brings my family together especially after a long day. Sharing this creamy, flavorful meal creates wonderful memories.

Notes

Add bell peppers or spinach for extra vegetables and color. Serve with crusty bread or a green salad. Pairs well with a chilled Sauvignon Blanc or light lager.

Required Tools

Large skillet with lid, Wooden spoon or spatula, Chefs knife, Cutting board, Measuring cups and spoons, Grater (for Parmesan)

Allergen Information

Contains dairy (butter, cream, Parmesan cheese) and gluten (orzo pasta). May contain traces of other allergens always check ingredient labels if sensitivity is a concern.

A bubbling skillet of One-Pot Cajun Chicken Alfredo Orzo, a quick, one-pan delicious dinner. Save
A bubbling skillet of One-Pot Cajun Chicken Alfredo Orzo, a quick, one-pan delicious dinner. | cloverhearth.com

This dish is perfect for quick weeknight dinners and always impresses guests with its rich flavors.

Recipe Questions & Answers

Can I substitute the chicken with another protein?

Yes, shrimp or Andouille sausage can be used as alternatives. Adjust cooking times accordingly to ensure proper doneness.

How can I reduce the richness of the sauce?

Using half and half instead of heavy cream and slightly reducing the Parmesan cheese will lighten the sauce without sacrificing flavor.

What pasta can I use instead of orzo?

Small pasta shapes like acini di pepe or small elbows work well as substitutes, providing a similar texture and absorption of flavors.

Is it possible to add vegetables to this dish?

Absolutely, tossing in bell peppers, spinach, or other quick-cooking vegetables adds color and nutrients to the meal.

What is the best way to season the chicken for this dish?

Season the diced chicken simply with salt and black pepper before searing, allowing the Cajun spices in the sauce to provide the main flavorful heat.

What cooking tools are needed?

A large skillet with lid, wooden spoon or spatula, chefs knife, cutting board, measuring cups, and a grater for the Parmesan are recommended.

One-Pot Cajun Chicken Alfredo

A creamy one-pot blend of tender chicken, orzo, and zesty Cajun sauce for busy weeknights.

Prep duration
10 minutes
Cook duration
20 minutes
Overall time
30 minutes
Recipe by Clover Hearth Emily Dawson

Recipe type One-Pot Comfort Meals

Skill level Easy

Culinary roots Cajun

Servings made 4 Portion size

Diet preferences None specified

What you'll need

Chicken

01 1 lb chicken breast, diced
02 Salt, to taste
03 Black pepper, to taste

Spice Blend

01 1 tbsp Cajun seasoning
02 1 tsp smoked paprika
03 1/4 tsp red pepper flakes (optional)

Base

01 2 tbsp olive oil
02 2 tbsp butter
03 1 medium onion, chopped
04 3 cloves garlic, minced

Pasta

01 1 cup orzo pasta

Sauce

01 2 cups low-sodium chicken broth
02 1 cup heavy cream
03 1 cup Parmesan cheese, freshly grated

Garnish

01 1 tbsp fresh parsley, chopped

How to make it

Step 01

Sear Chicken: Heat olive oil and butter in a large skillet over medium-high heat. Season diced chicken with salt and pepper. Sear for 3 to 4 minutes until golden brown, then remove and set aside.

Step 02

Sauté Aromatics: In the same skillet, add chopped onion and cook for 2 to 3 minutes until translucent. Add minced garlic and cook for 1 minute until fragrant.

Step 03

Toast Orzo: Add orzo pasta to the skillet and stir to combine. Toast for 1 to 2 minutes until lightly golden.

Step 04

Simmer Orzo: Pour in chicken broth and add Cajun seasoning, smoked paprika, and red pepper flakes. Stir thoroughly, bring to a boil, then reduce heat to low. Cover and simmer for 10 to 12 minutes, stirring occasionally, until orzo is al dente and most liquid is absorbed.

Step 05

Incorporate Cream and Cheese: Remove skillet from heat. Gradually stir in heavy cream and Parmesan cheese until sauce is creamy and smooth.

Step 06

Combine Chicken: Return cooked chicken to the skillet and stir to combine. Heat through for 1 minute. Adjust seasoning as necessary.

Step 07

Garnish and Serve: Sprinkle with fresh parsley before serving.

Equipment needed

  • Large skillet with lid
  • Wooden spoon or spatula
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons
  • Grater

Allergy details

Be sure to review every ingredient for potential allergies, and talk to a medical expert if you’re unsure.
  • Contains dairy and gluten

Nutrition information (each portion)

Only use this data as a helpful reference—it’s not intended to replace professional health guidance.
  • Calorie count: 560
  • Fat content: 28 grams
  • Carbohydrates: 45 grams
  • Proteins: 35 grams