High Protein Italian Beef and Pasta Bake

Featured in: Warm Family Dinners

This satisfying Italian-American bake combines whole wheat pasta with extra-lean ground beef and colorful vegetables including bell peppers, mushrooms, and fresh spinach. The dish gets its pizza-inspired character from turkey pepperoni and a generous blanket of melted mozzarella and Parmesan. With 33 grams of protein per serving, this lighter take on comfort food delivers substantial nutrition without sacrificing flavor. Perfect for meal prep or feeding a hungry family, everything comes together in one pan for easy cleanup.

Updated on Wed, 21 Jan 2026 16:44:00 GMT
Steaming High Protein Italian Beef and Pasta Bake features melty cheese, whole wheat penne, and sautéed veggies in a rich red sauce, topped with turkey pepperoni. Save
Steaming High Protein Italian Beef and Pasta Bake features melty cheese, whole wheat penne, and sautéed veggies in a rich red sauce, topped with turkey pepperoni. | cloverhearth.com

The first time I made this pasta bake was on a Tuesday when meal prep desperation met my craving for something that felt like comfort food but actually fueled my training. My apartment smelled like an Italian grandmother had moved in, and my roommate kept wandering into the kitchen asking if it was done yet. That week, having this ready in the fridge transformed my chaotic work schedule into something manageable. Now it is the recipe I turn to when I want food that works as hard as I do.

I brought this to a friend's potluck last month, and honestly, watching people go back for thirds was its own kind of reward. Someone asked for the recipe before they even finished their first plate. It is that kind of dish where people assume you spent hours, but the truth is it comes together while you catch up on podcasts or help kids with homework.

Ingredients

  • Whole wheat penne or rotini: The nutty flavor holds up perfectly to baking and keeps you fuller longer
  • Extra-lean ground beef: Brown it thoroughly and drain any excess fat for the best texture
  • Onion, garlic, bell pepper, and mushrooms: These vegetables create a flavor base that makes the sauce taste like it simmered all day
  • Baby spinach: Wilts down into the sauce so you barely notice it is there but get all the nutrition
  • Crushed tomatoes and tomato paste: The combination gives you a thick, rich sauce that coats every piece of pasta
  • Dried oregano and basil: Use what you have, but adding them early lets their oils bloom into the sauce
  • Part-skim mozzarella: Shreds beautifully and melts into those cheese pulls everyone loves
  • Grated Parmesan: Adds that salty umami punch that makes the whole dish taste restaurant quality
  • Turkey pepperoni: Totally optional, but if you want pizza vibes without the grease, this is your secret weapon

Instructions

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Get your oven ready:
Preheat to 200°C (400°F) and grab a 9x13 inch baking dish, giving it a quick spray of cooking spray so nothing sticks later.
Cook the pasta:
Boil that whole wheat pasta in salted water until it is just al dente, knowing it will finish cooking in the oven, then drain it well.
Brown the beef:
Cook the ground beef in a large skillet over medium heat, breaking it up with your spoon until it is nicely browned all over.
Sauté the vegetables:
Toss in your onion, garlic, bell pepper, and mushrooms, cooking them until they soften and your kitchen starts smelling amazing.
Add the spinach:
Stir in those baby spinach leaves and watch them wilt down into the mixture, which takes barely a minute.
Build the sauce:
Pour in the crushed tomatoes, tomato paste, and all your dried herbs and spices, then let everything simmer together for about 5 minutes.
Combine everything:
Mix that cooked pasta right into the beef and vegetable sauce until every piece is coated in red goodness.
Assemble the bake:
Transfer the whole mixture into your prepared baking dish, spreading it out evenly.
Add the cheese:
Sprinkle the mozzarella and Parmesan all over the top, and arrange those turkey pepperoni slices if you are using them.
Bake until bubbly:
Slide it into the oven for 20 minutes, until the cheese is melted and bubbling and you cannot wait another second.
Finish with fresh basil:
Scatter some fresh basil on top if you have it, then serve it up while it is steaming hot.
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Rinse produce, clean cookware, and fill pots smoothly with flexible spray options for everyday cooking.
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This hearty Italian-American casserole highlights tender ground beef, spinach, and bell peppers in a baked pasta dish with a crispy, golden cheese crust. Save
This hearty Italian-American casserole highlights tender ground beef, spinach, and bell peppers in a baked pasta dish with a crispy, golden cheese crust. | cloverhearth.com

This recipe saved me during a particularly hectic month when cooking dinner felt like climbing a mountain every single night. Now whenever I make it, I remember that relief of opening the refrigerator and seeing tomorrow's lunch already handled, ready to grab and go.

Making It Your Own

I have tried stirring in some low-fat cottage cheese right before baking, and it adds this incredible creaminess while bumping the protein even higher. If you are avoiding gluten, chickpea or lentil pasta works beautifully here and adds even more protein to the mix.

Vegetable Swaps That Work

Sometimes I will toss in black olives or roasted zucchini slices if I have them hanging around in the crisper drawer. The beauty of this dish is how forgiving it is, so use what you have and what your family actually likes to eat.

Serving Suggestions

A crisp green salad with a simple vinaigrette cuts through the richness perfectly and makes this feel like a complete meal. I also like to have some red pepper flakes on the table for anyone who wants to kick up the heat.

  • Let the bake rest for 5 minutes before serving so it sets up nicely
  • Cut into squares and pack for lunches that reheat beautifully
  • Store in the fridge for up to 4 days or freeze portions for busy weeks
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Serve this High Protein Italian Beef and Pasta Bake garnished with fresh basil, a side salad, and a warm slice of garlic bread for dinner. Save
Serve this High Protein Italian Beef and Pasta Bake garnished with fresh basil, a side salad, and a warm slice of garlic bread for dinner. | cloverhearth.com

There is something deeply satisfying about pulling this bubbling, cheese-topped dish out of the oven and watching everyone gather around the table. That first cheesy bite never disappoints.

Recipe Questions & Answers

Can I make this bake gluten-free?

Yes, substitute chickpea pasta or lentil pasta for the whole wheat pasta. These alternatives actually boost the protein content even higher while making the dish completely gluten-free.

How long do leftovers keep in the refrigerator?

Store individual portions in airtight containers for up to 4 days. The flavors actually improve after a day or two. Reheat in the microwave with a splash of water to prevent drying.

Can I freeze this pasta bake?

Absolutely. Assemble the entire dish, cover tightly with foil and plastic wrap, and freeze for up to 3 months. Thaw overnight in the refrigerator before baking, or add 10-15 minutes to the baking time if baking from frozen.

What vegetables work well in this dish?

Beyond the bell peppers, mushrooms, and spinach, try adding zucchini, eggplant, or black olives for Mediterranean flair. Roasted vegetables also add depth of flavor before mixing with the sauce.

How can I increase the protein content even more?

Stir 200 grams of low-fat cottage cheese or ricotta into the pasta mixture before baking. You can also mix in chopped cooked chicken or use high-protein pasta alternatives.

Is turkey pepperoni necessary?

Completely optional. Turkey pepperoni adds a pizza-inspired flavor with less fat than traditional pepperoni, but the bake is delicious without it. You can also use regular pepperoni or omit entirely.

High Protein Italian Beef and Pasta Bake

Hearty pasta bake featuring lean beef, whole wheat pasta, and vegetables under melted cheese. Modified for high protein and lower calories.

Prep duration
20 minutes
Cook duration
30 minutes
Overall time
50 minutes
Recipe by Clover Hearth Emily Dawson

Recipe type Warm Family Dinners

Skill level Easy

Culinary roots Italian-American

Servings made 6 Portion size

Diet preferences None specified

What you'll need

Pasta

01 10.5 oz whole wheat penne or rotini

Beef & Vegetables

01 1 lb extra-lean ground beef
02 1 medium onion, diced
03 2 cloves garlic, minced
04 1 red bell pepper, diced
05 3.5 oz mushrooms, sliced
06 3.5 oz baby spinach

Sauce

01 24 oz canned crushed tomatoes
02 2 tbsp tomato paste
03 1 tsp dried oregano
04 1 tsp dried basil
05 0.5 tsp chili flakes
06 Salt and freshly ground black pepper, to taste

Cheese & Toppings

01 5 oz part-skim mozzarella cheese, shredded
02 1 oz grated Parmesan cheese
03 1 oz turkey pepperoni slices
04 Fresh basil, for garnish

How to make it

Step 01

Preheat Oven: Preheat oven to 400°F.

Step 02

Cook Pasta: Cook pasta in a large pot of boiling salted water until al dente. Drain and set aside.

Step 03

Brown Ground Beef: In a large nonstick skillet over medium heat, cook the ground beef until browned, breaking it up as it cooks. Drain excess fat if needed.

Step 04

Sauté Vegetables: Add onion, garlic, bell pepper, and mushrooms to the skillet. Sauté for 5–7 minutes until softened.

Step 05

Add Spinach: Stir in spinach and cook until wilted, about 1 minute.

Step 06

Prepare Sauce: Add crushed tomatoes, tomato paste, oregano, basil, chili flakes, salt, and pepper. Simmer for 5 minutes, allowing flavors to meld.

Step 07

Combine Pasta and Sauce: Combine the cooked pasta with the beef and vegetable sauce mixture.

Step 08

Transfer to Baking Dish: Transfer the mixture to a lightly greased 9x13 inch baking dish.

Step 09

Add Cheese Toppings: Sprinkle mozzarella and Parmesan evenly over the top. Arrange turkey pepperoni slices if using.

Step 10

Bake: Bake for 20 minutes, until cheese is melted and bubbly.

Step 11

Garnish and Serve: Garnish with fresh basil before serving, if desired.

Equipment needed

  • Large pot
  • Large nonstick skillet
  • 9x13 inch baking dish
  • Mixing spoon
  • Cheese grater

Allergy details

Be sure to review every ingredient for potential allergies, and talk to a medical expert if you’re unsure.
  • Contains wheat (pasta)
  • Contains milk (cheese, optional cottage or ricotta cheese)
  • May contain soy (check processed meat or cheese labels)

Nutrition information (each portion)

Only use this data as a helpful reference—it’s not intended to replace professional health guidance.
  • Calorie count: 370
  • Fat content: 11 grams
  • Carbohydrates: 37 grams
  • Proteins: 33 grams